| Title |
Microencapsulation of a-Tocopherol Using Hydroxypropyl Cellulose-Blended Sodium Alginate |
|
Authors |
Guerrero, Rodel D.; Casalme, Lara Angelica R.; Nalzaro, Paul Jake B.; Osabel, Raymund Joseph N.; Pescos, Charisse Joy H.; Tumolva, Terence P. |
|
Publication date |
2016/12 |
|
Conference |
2016 International Conference on Materials and Chemical Engineering |
| Abstract |
Vitamin E is a micronutrient essential to human health with one of its isoforms, 脙聝脗聝脙聜脗聨脙聝脗聜脙聜脗卤-tocopherol, functioning as a chain-breaking antioxidant. However, it is only partially absorbed at the intestinal site where vitamins should be transported, thereby reducing its bioavailability. In order to protect an encapsulated drug from degradation, microencapsulation can be applied. Hence, it is this study脙聝脗聝脙聜脗垄脙聝脗聜脙聜脗聙脙聝脗聜脙聜脗聶s aim to synthesize and characterize microencapsulated 脙聝脗聝脙聜脗聨脙聝脗聜脙聜脗卤-tocopherol. The microcapsules were synthesized with the use of different mixtures of sodium alginate and hydroxypropyl cellulose as the coating material, and calcium chloride as the hardening agent. SEM images show that 25:75 alginate-HPC ratio is incapable of encapsulating the drug while the 100:0, 75:25, and 50:50 ratios are capable, as supported by FTIR results. Morphological analysis show that microcapsules are larger and more spherical with increasing alginate content. It was also found out that at 54.75%, the 50:50 blending ratio is the most efficient in encapsulating the drug. Lastly, the swelling test shows that the microcapsules would be able to traverse the acidic environment of the stomach (pH = 1.2), targeting the intestines (pH = 7.4) for the intended drug release where the microcapsules disintegrate. |
| Index terms / Keywords |
a-tocopherol, sodium alginate, hydroxypropyl cellulose, microencapsulation |
Mindanao State
University - Iligan Institute of Technology