| Title |
Antiproliferative property of sea fan extracts against colon (HCT 116) and lung (A549) cancer cell lines |
|
Authors |
Chona Gelani, Kristia Gail Palubon, Chrisma Anna Fe Galvez, Francis Limbag |
|
Conference |
67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research |
| Abstract |
The Philippines is endowed with rich marine resources, which, for the most part, is still untapped. In this
study, we explored the potential of the bioactive fractions from sea fans with the hope of finding drug
candidates for cancer treatment. Sea fan samples were collected from the island of Mindanao. Bioactivity-guided
separation of polar and nonpolar extracts were done using colon (HCT116) and lung (A549)
mammalian cancer cell lines employing the MTT assay. Chromatographic separation afforded a nonpolar
(hexane) fraction Ellisella sp.which exhibited a percent cell viability of 30.1 脗卤 0.1 at 30 mcg/mL against
HCT116. Its IC50 was calculated to be 31 mcg/mL. Semi-purification of this extract is ongoing. Other sea
fan polar and nonpolar extracts showed noncytotoxic to mildly cytotoxic activities against both colon and
lung cancer cell lines. The antibacterial property of these extracts was also determined. |
| Index terms / Keywords |
sea fans, antiproliferative property, cancer cell lines |
Mindanao State
University - Iligan Institute of Technology