| Title |
Bioactive Zn-doped hydroxyapatite coatings and their antibacterial efficacy against Escherichia coli and Staphylococcus aureus |
|
Authors |
Rachele Sergi, Devis Bellucci, Rolando T. Candidato, Jr., Luca Lusvarghi, Giovanni Bolelli, Lech Pawlowski, Gabriele Candiani, Lina Altomare, Luigi De Nardo, Valeria Cannillo |
|
Publication date |
2018/08/06 |
|
Journal |
SURFACE AND COATINGS TECHNOLOGY |
| Volume |
Volume 352 |
| Pages |
8 pages |
| Publisher |
Elsevier |
| Abstract |
Zinc-doped hydroxyapatite (HA+Zn) has aroused increasing interest in bone contact applications, for its capacity
to modulate osteoblast activity and for the antibacterial properties of zinc ions. In this study, HA+Zn
coatings deposited by the Solution Precursor Plasma Spraying (SPPS) process were characterized. This method
employs solution feedstocks providing simple and effective ion doping and resulting in the deposition of lamellae
of smaller size than the conventional Atmospheric Plasma Spraying method. After a comprehensive microstructural
characterization of the coatings, their bioactivity, cytotoxicity, and antibacterial efficacy were investigated.
The coatings' bioactivity was confirmed by soaking them in Simulated Body Fluid (SBF), a commonlyused
protocol to evaluate samples' bioactivity in vitro. Further, the coatings were non-cytotoxic against human
osteoblast Saos-2-cells and, additionally, they showed antibacterial effects against Escherichia coli and
Staphylococcus aureus. The HA+Zn coatings obtained showed higher efficacy against the gram-positive S. aureus
than against the gram-negative Escherichia coli. These findings demonstrate the potential of the SPPS method for
fabricating Zn-doped hydroxyapatite coatings, and show that Zn ions impart antibacterial properties against E.
coli and S. aureus bacteria |
| Index terms / Keywords |
Antibacterial effect, Cytotoxicity, Zinc doped hydroxyapatite, SBF, SPPS |
| DOI |
|
Mindanao State
University - Iligan Institute of Technology