| Title |
Beta-catenin signaling regulates Foxa2 expression during endometrial hyperplasia |
|
Authors |
M Villacorte, K Suzuki, Akira Hirasawa, Y Ohkawa, M Suyama, T Maruyama, Daisuke Aoki, Y Ogino, Shinichi Miyagawa, T Terabayashi, Y Tomooka, N Nakagata, G Yamada |
|
Publication date |
2013/7 |
|
Journal |
Oncogene |
| Volume |
32 |
| Issue |
29 |
| Pages |
3477-3482 |
| Publisher |
Nature Publishing Group |
| Abstract |
The Wnt/脦虏-catenin signaling is essential for various organogenesis and is often implicated during tumorigenesis. Dysregulated 脦虏-catenin signaling is associated with the formation of endometrial adenocarcinomas (EACs), which is considered as the common form of endometrial cancer in women. In the current study, we investigate the downstream target of Wnt/脦虏-catenin signaling in the uterine epithelia and the mechanism leading to the formation of endometrial hyperplasia. We report that conditional ablation and activation of 脦虏-catenin in the uterine epithelia lead to aberrant epithelial structures and endometrial hyperplasia formation, respectively. We demonstrate that 脦虏-catenin regulates Foxa2 with its candidate upstream region for the uterine epithelia. Furthermore, knockdown of Foxa2 leads to defects in cell cycle regulation, suggesting a possible function of Foxa2 in the control of cell proliferation. We also observe that 脦虏-catenin and Foxa2 expression levels are augmented in the human specimens of complex atypical endometrial hyperplasia, which is considered to have a greater risk of progression to EACs. Thus, our study indicates that 脦虏-catenin regulates Foxa2 expression, and this interaction is possibly essential to control cell cycle progression during endometrial hyperplasia formation. Altogether, the augmented expression levels of 脦虏-catenin and Foxa2 are essential features during the formation of endometrial hyperplasia. |
| Index terms / Keywords |
Beta-catenin; Foxa2; endometrial hyperplasia; grafting |
| DOI |
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| URL |
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Mindanao State
University - Iligan Institute of Technology