| Title |
Preparation of Crosslinked Alginate-Cellulose Derivative Microparticles for Protein Delivery |
|
Authors |
Guerrero, Rodel D.; Heng, Paul WS; and Tumolva, Terence P. |
|
Publication date |
2022/09/09 |
|
Journal |
Key Engineering Materials |
| Volume |
931 |
| Pages |
69-75 |
| Publisher |
Trans Tech Publications, Ltd. |
| Abstract |
Microparticle protein delivery system using alginate and cellulose derivative (HPC, HEC and CMC) composite system was prepared using external gelation with vibration technology. Bovine serum albumin (BSA) as a model protein was encapsulated using these biodegradable materials. This preparation showed an increase in encapsulation efficiency in comparison to the samples where pure alginate was used as the encapsulating material. Compared with the other microparticles, the 50:50 alginate/HEC samples exhibited significant encapsulation efficiency. Consequently, its release rate in the acidic medium was comparatively substantial and higher cumulative release in the simulated intestinal fluid (SIF) medium at the end of the dissolution study was observed to be high at around 86.17%. |
| Index terms / Keywords |
Alginate, Cellulose, Ionotropic Gelation, Microencapsulation, Protein |
| DOI |
|
| URL |
|
Mindanao State
University - Iligan Institute of Technology